A novel approach to study markers of dopamine signaling in peripheral immune cells. Gopinath A, Doty A, Mackie PM, Hashimi B, Francis M, Saadatpour L, Saha K, Shaw G, Ramirez-Zamora A, Okun MS, Streit WJ, Khoshbouei H. J Immunol Methods. 2019 Oct 18:112686. doi: 10.1016/j.jim.2019.112686. PMID: 31634479

Methamphetamine regulation of activity and topology of ventral midbrain networks. Miller DR, Lebowitz JJ, Guenther DT, Refowich AJ, Hansen C, Maurer AP, Khoshbouei H.PLoS One. 2019 Sep 19;14(9):e0222957. doi: 10.1371/journal.pone.0222957. eCollection 2019. PMID: 31536584

Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway. Nickoloff-Bybel EA, Mackie P, Runner K, Matt SM, Khoshbouei H, Gaskill PJ.Brain Behav Immun. 2019 Aug 27. pii: S0889-1591(19)30115-1. doi: 10.1016/j.bbi.2019.08.191. PMID: 31470080

Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension. Ahmari N, Santisteban MM, Miller DR, Geis NM, Larkin R, Redler T, Denson H, Khoshbouei H, Baekey DM, Raizada MK, Zubcevic J. Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H279-H289. doi: 10.1152/ajpheart.00510.2018. Epub 2019 May 31. PMID: 31150271

PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux. Zhou Y, Miles JR, Tavori H, Lin M, Khoshbouei H, Borchelt DR, Bazick H, Landreth GE, Lee S, Fazio S, Notterpek L.J Neurosci. 2019 Jul 3;39(27):5404-5418. doi: 10.1523/JNEUROSCI.2942-18.2019. Epub 2019 May 6. PMID: 31061090

Clustered Kv2.1 decreases dopamine transporter activity and internalization. Lebowitz JJ, Pino JA, Mackie PM, Lin M, Hurst C, Divita K, Collins AT, Koutzoumis DN, Torres GE, Khoshbouei H. J Biol Chem. 2019 Apr 26;294(17):6957-6971. doi: 10.1074/jbc.RA119.007441. Epub 2019 Mar 1. PMID: 30824538

Methamphetamine neurotoxicity, microglia, and neuroinflammation. Shaerzadeh F, Streit WJ, Heysieattalab S, Khoshbouei H. J Neuroinflammation. 2018 Dec 12;15(1):341. doi: 10.1186/s12974-018-1385-0. Review. PMID: 30541633

Microglial activation occurs late during preclinical Alzheimer's disease. Streit WJ, Braak H, Del Tredici K, Leyh J, Lier J, Khoshbouei H, Eisenlöffel C, Müller W, Bechmann I. Glia. 2018 Dec;66(12):2550-2562. doi: 10.1002/glia.23510. Epub 2018 Nov 11. PMID: 30417428

Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine. Salvatore MF, Nejtek VA, Khoshbouei H. Neurotoxicology. 2018 Jul;67:121-128. doi: 10.1016/j.neuro.2018.05.003. Epub 2018 May 18. PMID: 29782882 

Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension. Sharma RK, Oliveira AC, Kim S, Rigatto K, Zubcevic J, Rathinasabapathy A, Kumar A, Lebowitz JJ, Khoshbouei H, Lobaton G, Aquino V, Richards EM, Katovich MJ, Shenoy V, Raizada MK.  Hypertension. 2018 Jun;71(6):1156-1163. doi: 10.1161/HYPERTENSIONAHA.118.10934.  PMID: 29712738

HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific.  Miller DR, Shaerzadeh F, Phan L, Sharif N, Gamble-George J, McLaughlin JP, Streit WJ, Khoshbouei H.  Glia. 2018 May 7. doi: 10.1002/glia.23447.  PMID: 29733459

Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone. Colon-Perez LM, Pino JA, Saha K, Pompilus M, Kaplitz S, Choudhury N, Jagnarine DA, Geste JR, Levin BA, Wilks I, Setlow B, Bruijnzeel AW, Khoshbouei H, Torres GE, Febo M. Neuropharmacology. 2018 May 3;137:178-193. doi: 10.1016/j.neuropharm.2018.04.031.  PMID: 29729891

Glial cells modulate hippocampal synaptic plasticity in morphine dependent rats. Elahi-Mahani A, Heysieattalab S, Hosseinmardi N, Janahmadi M, Seyedaghamiri F, Khoshbouei H. Brain Res Bull. 2018 Apr 17;140:97-106. doi: 10.1016/j.brainresbull.2018.04.006.  PMID: 29678774

Hippocampal glial cells modulate morphine-induced behavioral responses. Seyedaghamiri F, Heysieattalab S, Hosseinmardi N, Janahmadi M, Elahi-Mahani A, Salari F, Golpayegani M, Khoshbouei H. Physiol Behav. 2018 Jul 1;191:37-46. doi: 10.1016/j.physbeh.2018.04.003. Epub 2018 Apr 4. PMID: 29626506

The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease. Mackie P, Lebowitz J, Saadatpour L, Nickoloff E, Gaskill P, Khoshbouei H. Brain Behav Immun. 2018 Mar 15. pii: S0889-1591(18)30071-0. doi: 10.1016/j.bbi.2018.03.020. PMID: 29551693

The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. Sambo DO, Lebowitz JJ, Khoshbouei H. Pharmacol Ther. 2018 Jan 29. pii: S0163-7258(18)30016-0. doi: 10.1016/j.pharmthera.2018.01.009.  PMID: 29360540

The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.  Sambo D, Lin M, Owens A, Lebowitz J, Richardson B, Jagnarine D, Shetty M, Rodriguez M, Alonge T, Ali M, Katz J, Yan L, Febo M, Henry K, Bruijnzeel A, Dawes L, Khoshbouei H. Nat Commun. 2017 Dec 20;8(1):2228. doi:10.1038/s41467-017-02087-x. PMID: 29263318

Methamphetamine Regulation of Firing Activity of Dopamine Neurons.  Lin M, Sambo D, Khoshbouei H. Journal of Neurosci. 2016 Oct 5;36(40):10376-10391. PMID: 27707972

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.  Sacino AN, Brooks MM, Chakrabarty P, Saha K, Khoshbouei H, Golde TE, Giasson BI. J Neurochem. 2017 Feb;140(4):662-678. doi: 10.1111/jnc.13743. Epub 2016 Aug 19. PMID: 27424880

Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR. J Neurosci. 2018 Jan 10;38(2):484-497. doi: 10.1523/JNEUROSCI.2604-17.2017. Epub 2017 Nov 24. PMID: 29175958

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF. PLoS One. 2017 May 3;12(5):e0173565. doi: 10.1371/journal.pone.0173565. eCollection 2017. PMID: 28467418 

HIV, Tat and dopamine transmission. Gaskill PJ, Miller DR, Gamble-George J, Yano H, Khoshbouei H. Neurobiol Dis. 2017 Sep;105:51-73. doi: 10.1016/j.nbd.2017.04.015. Epub 2017 Apr 27. Review. PMID: 28457951

Alpha-synuclein modulates dopamine neurotransmission.  Butler B, Sambo D, Khoshbouei H. J Chem Neuroanat. 2016 Jun 19. pii: S0891-0618(16)30068-0. doi: 10.1016/j.jchemneu.2016.06.001. [Epub ahead of print] Review. PMID: 27334403

Methamphetamine-induced enhancement of hippocampal long-term potentiation is modulated by NMDA and GABA receptors in the shell-accumbens.  Heysieattalab S, Naghdi N, Hosseinmardi N, Zarrindast MR, Haghparast A, Khoshbouei H. Synapse. 2016 Aug;70(8):325-35. doi: 10.1002/syn.21905. Epub 2016 Apr 15. PMID: 27029021

Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane.  Richardson BD, Saha K, Krout D, Cabrera E, Felts B, Henry LK, Swant J, Zou MF, Newman AH, Khoshbouei H. Nat Commun. 2016 Jan 25;7:10423. doi: 10.1038/ncomms10423. PMID: 26804245

The effects of GABAA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats.  Heysieattalab S, Naghdi N, Zarrindast MR, Haghparast A, Mehr SE, Khoshbouei H. Pharmacol Biochem Behav. 2016 Mar;142:23-35. doi: 10.1016/j.pbb.2015.12.008. Epub 2015 Dec 18. PMID: 26708956

Dopamine Transporter Activity Is Modulated by α-Synuclein.  Butler B, Saha K, Rana T, Becker JP, Sambo D, Davari P, Goodwin JS, Khoshbouei H. J Biol Chem. 2015 Dec 4;290(49):29542-54. doi: 10.1074/jbc.M115.691592. Epub 2015 Oct 6. PMID: 26442590

Dopamine Transporter Activity Is Modulated by α-synuclein. Butler B, Goodwin S, Saha K, Becker J, Sambo D, Davari P, Khoshbouei H. J Biol Chem. 2015 Jun 5. pii: jbc.M115.639880. doi: 10.1074/jbc.M115.639880. Epub 2015 Jun 5. Retraction in: J Biol Chem. 2015 Jul 31;290(31):19009. PMID: 26048988

Intracellular Methamphetamine Prevents the Dopamine-induced Enhancement of Neuronal Firing.  Saha K, Sambo D, Richardson BD, Lin LM, Butler B, Villarroel L, Khoshbouei H J Biol Chem. 2014 Aug 8;289(32):22246-57. doi: 10.1074/jbc.M114.563056. Epub 2014 Jun 24. PMID: 25621291

The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.  Roth JA, Li Z, Sridhar S, Khoshbouei H. Neurotoxicology. 2013 Mar; 35: 121-8. doi: 10.1016/j.neuro.2013.01.002 Epub 2013 Jan 11. PMID: 23313730

Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.  North A, Swant J, Salvatore MF, Gamble-George J, Prins P, Butler B, Mittal MK, Heltsley R, Clark JT, Khoshbouei H. Synapse. 2013 May;67(5):245-57. doi: 10.1002/syn.21635. Epub 2013 Feb. 8 PMID: 23280858

Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry.  Saha K, Swant J, Khoshbouei H. J Vis Exp. 2012 Nov 21;(69). pii: 3798. doi: 10.3791-3798. PMID: 23207721

α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter.  Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H.  J Biol Chem. 2011 Dec 23;286(51):43933-43. Epub 2011 Oct 11. PMID: 21990355

Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus.  Swant J, Chirwa S, Stanwood G, Khoshbouei H.  PLoS One. 2010 Jun 30;5(6):e11382. PMID: 20614033

Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.  Goodwin JS, Larson GA, Swant J, Sen N, Javitch JA, Zahniser NR, De Felice LJ, Khoshbouei H.  J Biol Chem. 2009 Jan 30;284(5):2978-89. Epub 2008 Dec 1. PMID: 19047053

PI3K signaling supports amphetamine-induced dopamine efflux.  Lute BJ, Khoshbouei H, Saunders C, Sen N, Lin RZ, Javitch JA, Galli A. Biochem Biophys Res Commun. 2008 Aug 8;372(4):656-61. Epub 2008 May 27. PMID: 18510945

Amphetamine induces dopamine efflux through a dopamine transporter channel. Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A.  Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3495-500. Epub 2005 Feb 22. PMID: 15728379

Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice. Butler B, Gamble-George J, Prins P, North A, Clarke JT, Khoshbouei H. J Addict Prev. 2014;2(2). pii: 6. PMID: 25621291

PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. Toxicol Sci. 2012 Jan;125(1):233-47. doi: 10.1093/toxsci/kfr261. Epub 2011 Oct 10. PMID: 21987461

Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function. McCallister MM, Maguire M, Ramesh A, Aimin Q, Liu S, Khoshbouei H, Aschner M, Ebner FF, Hood DB. Neurotoxicology. 2008 Sep;29(5):846-54. doi: 10.1016/j.neuro.2008.07.008. Epub 2008 Aug 9. PMID: 18761371

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Fog JU, Khoshbouei H, Holy M, Owens WA, Vaegter CB, Sen N, Nikandrova Y, Bowton E, McMahon DG, Colbran RJ, Daws LC, Sitte HH, Javitch JA, Galli A, Gether U. Neuron. 2006 Aug 17;51(4):417-29. PMID: 16908408

Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Gnegy ME, Khoshbouei H, Berg KA, Javitch JA, Clarke WP, Zhang M, Galli A. Mol Pharmacol. 2004 Jul;66(1):137-43. PMID: 15213305

N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. Khoshbouei H, Sen N, Guptaroy B, Johnson L', Lund D, Gnegy ME, Galli A, Javitch JA. PLoS Biol. 2004 Mar;2(3):E78. Epub 2004 Mar 16. PMID: 15024426

Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress. Morilak DA, Cecchi M, Khoshbouei H. Life Sci. 2003 Jun 27;73(6):715-26. Review. PMID: 12801593

Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. Khoshbouei H, Wang H, Lechleiter JD, Javitch JA, Galli A. J Biol Chem. 2003 Apr 4;278(14):12070-7. Epub 2003 Jan 29. PMID: 12556446

Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress. Cecchi M, Khoshbouei H, Morilak DA. Neuropharmacology. 2002 Dec;43(7):1139-47. PMID: 12504920

Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Khoshbouei H, Cecchi M, Morilak DA. Neuropsychopharmacology. 2002 Jul;27(1):25-34. PMID: 12062904

Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Cecchi M, Khoshbouei H, Javors M, Morilak DA. Neuroscience. 2002;112(1):13-21. PMID: 12044468

Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala. Khoshbouei H, Cecchi M, Dove S, Javors M, Morilak DA. Pharmacol Biochem Behav. 2002 Mar;71(3):407-17. PMID: 11830175

Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. Kolakowski LF Jr, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF. J Neurochem. 1998 Dec;71(6):2239-51. PMID: 9832121