Our research is to understand how the dopamine transporter (DAT) regulates biological responses, and how this regulation is modulated by structural differences in ligands acting at DAT and by DAT-interacting proteins such as alpha-synuclein and Sigma-1Receptor. As an example, by discovering the mechanisms by which the DAT ligand methamphetamine induces its unique addictive qualities, we will not only reveal novel therapeutic targets for intervention/prophylaxis of disorders associated with dysregulation of the dopaminergic system, but almost certainly ascertain new molecular mechanisms for transporter-effected signal transduction. Finally, I also intend that my research laboratory will provide an outstanding venue for the training of undergraduate, doctoral and post-doctoral trainees. Please feel free to contact us for additional information.
Habibeh Khoshbouei, Pharm.D., Ph.D.
Department of Neuroscience
Department of Psychiatry
McKnight Brain Institute of the University of Florida